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Test results of C6 telomer related substances

Clicking on the substance name will lead to our site where the results of toxicology studies for the named substances have been uploaded.

PFHxA(Perfluorohexanoic Acid: C5F11COOH)

   Items Report Date Language Result
Environmental effects Fish Early-Life Stage Toxicity Test and Amendments  (APFHx)1 01-Aug-08 English NOEC for hatching success, post-hatch larval survival, for fish total lengths and fish dry weights  = 10 mg/L
Fish Early-Life Stage Toxicity Test and Amendments  (APFHx)2
Fish Early-Life Stage Toxicity Test and Amendments  (APFHx)3
A 96-hour Acute Toxicity Study of perfluorohexanoic acid, annnonium salt in Medaka 24-Mar-16 English 96-hour LC50 = 1850mg/L
A 96-hour Acute Toxicity Study of perfluorohexanoic acid, sodium salt in Medaka 24-Mar-16 English 96-hour LC50 =3080mg/L
Fish Short Term Reproduction Assay of perfluorohexanoic acid, ammonium salt or sodium salt in Medaka 25-Dec-15 English There was no significant difference between VTG concentration of control and that of exposure levels.
Activated sludge respiration inhibition test 01-Jun-17 English Inhibition of respiration was not observed at 1000mg/L
A 48-hour Acute Immobilization Study of APFHx in Daphnia magna 02-Jun-17 English 48-hour EC50 >100mg/L
Algae growth inhibition study in Peudokirchneriella subcapitata 11-Jul-17 English EC50 >100mg/L
Developmental toxicity test with enbryo of zebrafish 07-May-18 English NOEC for the frequency of morphogical abnormalities was 500 mg/L
Measurement of 1-octanol/water partition coefficient 15-Mar-18 English logPow=2.1(undissociated from at pH2.0)
logPow=1.5 (dissociated from at pH7.4)
Estimation of the adsorption coefficient on soil and on sewage sludge 15-Mar-18 English logKoc=4.27(undissociated from at pH2.0)
logKoc<1.25 (dissociated from at pH7.0)
Measurement of water solubility 02-Mar-18 English >250g/L
Dissociation constants in water 01-Mar-18 English pKa=3.29
Health effects 7-day Repeated Dose Oral Toxicity in Rat 25-Oct-06 English No abnormalities were found in general status of health, weight, liver weight and necropsy after 7-day dosing.
Acute Oral Toxicity in Rat 09-May-18 English GHS Category 4
Acute Derma Toxicity in Rat 09-May-18 English LD50 > 2000mg/kg
Acute Eye Irritation/Corrosion in Rabbit 21-Jun-04 English GHS Category 1: having irreversible effects on the eyes
In vitro skin corrosion test using EpiDerm SCT 11-May-18 English Corossive(GHS 1B/1C)
Direct Peptide reactivit assay 03-Apr-17 English It was classified do high reactivity. The skin sensitivity was predicted as "Posivitive".
Human Cell Line Activation test 04-Apr-17 English The skin sensitivity was predicted as "Posivitive".
Local lymph node assay 01-Jun-17 English The skin sensitivity was predicted as "Posivitive".
Bacterial Reverse Mutation Assay 03-Apr-17 English Negative
Chromosomal aberration test using cultured mammalian cells 03-Jul-17 English Negative
In Vitro Mammalian Cell Gene Mutation Tests using the Hprt genes 25-Jan-18 English No mutagenic effect
24-Month Oral (Gavage) Combined Chronic Toxicity/Carcinogenicy(PFHx) 11-May-07 English NOEL for non-neoplastic systemic toxicity:15mg/kg/day(male), 30mg/kg/day(female)
NOEL for neoplastic:100mg/kg/day(male), 200mg/kg/day(female) 
The Excretion of [14C]-Ammonium Perfluorohexanoate in the Mouse and the Rat Following a Single Oral Administration at 50 mg/kg  27-Nov-09 English Excretion of total radioactivity(24 h post dose)
Rat: male=95.6%, female=99.2%
Mice: male=90.9%, female=94.1% 
The Excretion and Tissue Distribution of [14C]-Ammonium Perflourohexanoate in the Mouse and the Rat Following a Multiple Oral Administration of 50 mg/kg 27-Nov-09 English Excretion of total radioactivity(24 h post dose)
Rat: male=93.7%, female=90.4%
Mice: male=93.5, female=92.2%
Oral (Gavage) Acute Pharmacokinetic Study of PFH Ammonium Salt (Ammonium salt of Perflourinated Hexanoic Acid) in Mice 14-May-10 English Half life of female mice
35mg/kg 0.889h
175mg/kg 1.24mg/kg
350mg/kg 0.924mg/kg
Evaluation of PFHx- Pharmacokinetics in Mouse, Rat, Microminipig, Pig, Monkey and Human 29-Mar-16 English There are no significant
pharmacokinetic differences across mice, rats, monkeys, pigs, and humans.
Developmental toxicity study in rats 26-Apr-07 English NOAEL for maternal and developmental toxicity was 100 mg/kg/day
Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of PFH Ammonium Salt (Ammonium salt of Perfluorinated Hexanoic Acid) in Mice1 26-Jul-11 English maternal NOEL = 175mg/kg
F1 NOAEL = 35mg/kg
Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of PFH Ammonium Salt (Ammonium salt of Perfluorinated Hexanoic Acid) in Mice2
Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of PFH Ammonium Salt (Ammonium salt of Perfluorinated Hexanoic Acid) in Mice and Amendment 25-Aug-11
28-Sept-12
English maternal NOEL = 100mg/kg
F1 NOAEL = 100mg/kg
Posters and Paper A 24-Month Oral Combined Chronic Toxicity/Carcinogenicity Study of Perfluorohexanoic Acid (PFHxA) in Rats Society of Toxicological Pathology 2011 English See above
Ecotox and Pk findings for ammonium perfluorohexanoate (APFHx) PFAA Days III 2010 English See above
Ecotox Findings for Ammonium Perfluorohexanoate SETAC 2011 English See above
Combined developmental and perinatal/postnatal reproduction oral toxicity study of ammonium perfluorohexanoate in mice Society of Toxicology Annual Meeting 2012 English See above
Toxicokinetics of Ammonium Perfluorohexanoate Drug and Chemical Toxicology, 2011 34(4) 341 - 346 English See above
Evaluation of the chronic toxicity and carcinogenicity of perfluorohexanoic acid (PFHxA) in Sprague-Dawley rats Toxicol Pathol, 2015
43; 209-220
English See above
Oral (Gavage) Combined Developmental and Perinatal/Postnatal Reproduction Toxicity Study of Ammonium Salt of Perfluorinated Hexanoic Acid in Mice International journal of toxicology, 2014 33; 219-237 English See above

C6-2 Acid(C6F13CH2COOH)

   Items Report Date Language Result
Health effects 28-day Repeated Dose Oral Toxicity study in Rat 27-Jul-07 Japanese NOAEL: 1mg/kg/day
Bacterial Reverse Mutation Test (Ames test) 01-Mar-07 Japanese Negative
Chromosomal Aberration Study in Cultured Mammalian Cells 02-May-07 English Positive
( Numeric abberation: Positive )
( Structural abberation: Positive )
Environmental effects Acute Toxicity Test of with (Medaka) (Oryzias latipes) 25-May-07 Japanese 96h LC50:>100mg/L
Acute Immobilization Test with Daphnia magna 28-May-07 Japanese 48h EC50:83.5mg/L
Growth Inhibition Test with Pseudokirchneriella subcapitata 25-May-07 Japanese 72h ErC50:>100mg/L
NOEC :4.27mg/L
Bioconcentration Study with Carp 20-Jun-07 Japanese High conc.(20βg/L):<1.1
Low conc.(2βg/L):<12

C6-2 Alcohol(C6F13CH2CH2OH)

   Items Report Date Language Result
Health effects 28-day Repeated Dose Oral Toxicity study in Rat 25-Jul-07 English NOAEL: 5mg/kg/day
Bacterial Reverse Mutation Test (Ames test) 14-Feb-07 English Negative
Chromosomal Aberration Study in Cultured Mammalian Cells 26-Mar-07 English Positive
( Numeric abberation: Negative )
( Structural abberation: Positive )
Environmental effects Acute Toxicity Test of with (Medaka) (Oryzias latipes) 26-Jul-07 English 96h LC50:5.78mg/L
Acute Immobilization Test with Daphnia magna 28-May-07 Japanese 48h EC50:8.20mg/L
Growth Inhibition Test with Pseudokirchneriella subcapitata 25-May-07 Japanese 72h ErC50:>5.19mg/L
NOEC :1.47mg/L
Bioconcentration Study with Carp 19-Mar-07 English High conc.(10βg/L):-
Low conc.(1βg/L):29

C6-2Olefin(C6F13CH=CH2)

   Items Report Date Language Result
Health effects 28-day Repeated Dose Oral Toxicity study in Rat 24-Aug-07 English NOAEL: 5mg/kg/day
Bacterial Reverse Mutation Test (Ames test) 15-Feb-07 English Negative
Chromosomal Aberration Study in Cultured Mammalian Cells 14-Mar-07 English Negative
Environmental effects Acute Toxicity Test of with (Medaka) (Oryzias latipes) 19-Sep-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Acute Immobilization Test with Daphnia magna 10-Sep-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Growth Inhibition Test with Pseudokirchneriella subcapitata 18-Sep-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Biodegradation study by microoganisms 15-Mar-07 English Not biodegraded by microorganisms
Bioconcentration Study with Carp 19-Jul-07 English High conc.(1βg/L):380
Low conc.(0.1βg/L):300


C6SFA(CH2=CH-COOCH2CH2C6F13)

   Items Report Date Language Result
Health effects Acute oral toxicity in the rat- fixed dose method 10-May-07 English LD50 > 2000mg/kg
Acute eye irritation in the rabbit 28-May-07 English Minimal irritant
Acute eye irritation in the rabbit amendment 04-Aug-10 English GHS: not classified
Acute dermal irritation in the rabbit 03-Apr-07 English Mild irritant
Acute dermal irritation in the rabbit amendment 04-Aug-10 English GHS: not classified
Local lymph node assay in the mouse 11-May-07 English Non-sensitiser
28-day Repeated Dose Oral Toxicity study in Rat 15-Jun-07 English See below
28-day Repeated Dose Oral Toxicity study in Rat :Confirm the NOAEL Study 16-Apr-14 English NOAEL: 30mg/kg/day
(based on the latest toxic evaluation)
Bacterial Reverse Mutation Test (Ames test) 14-Feb-07 English Negative
Chromosomal Aberration Study in Cultured Mammalian Cells 26-Mar-07 English Negative
Gene mutation assay in Chinese hamster V79 cells In Vitro 12-Jun-08 English Negative
In vivo mouse bone marrow micronucleus assay 14-Mar-08 English Negative
Environmental effects Acute Toxicity Test of with (Medaka) (Oryzias latipes) 25-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Acute Immobilization Test with Daphnia magna 26-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Growth Inhibition Test with Pseudokirchneriella subcapitata 25-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Activated Sludge, Respiration Inhibition Test 18-Dec-12 English 3h EC50 > 1000mg/L
Biodegradation study by microoganisms 01-Feb-07 English Some of the test item was converted into C6-2acid, C6-2Alcohol
Bioconcentration Study with Carp 27-Jun-14 English High conc. (10μg/L): >8.0-10
Low conc. ( 1μg/L): >80
Determination of pH-dependent hydrolysis in water 28-Mar-13 English % decrease within 5 days (50℃)
pH=4 : 87%
pH=7 : 83%
pH=9 : >99%

C6SFMA(CH2=CCH3-COOCH2CH2C6F13)

   Items Report Date Language Result
Health effects Acute oral toxicity in the rat- fixed dose method 11-May-07 English LD50 > 2000mg/kg
Acute eye irritation in the rabbit 28-May-07 English Minimal irritant
Acute dermal irritation in the rabbit 28-May-07 English Mild irritant
Local lymph node assay in the mouse 15-May-07 English Non-sensitiser
28-day Repeated Dose Oral Toxicity study in Rat 10-Jul-07 English NOAEL: 5mg/kg/day
Bacterial Reverse Mutation Test (Ames test) 04-Aug-06 English Negative
Chromosomal Aberration Study in Cultured Mammalian Cells 14-Mar-07 English Negative
Environmental effects Acute Toxicity Test of with (Medaka) (Oryzias latipes) 25-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Acute Immobilization Test with Daphnia magna 26-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Growth Inhibition Test with Pseudokirchneriella subcapitata 25-Jul-07 English The test item has no acute toxicity to the test organisms at the concentration around the solubility.
Biodegradation study by microoganisms 15-Mar-07 English Some of the test item was converted into C6-2acid, C6-2Alcohol